Anti-inflammatory, Analgesic and Antipyretic Effects of Mollugo Pentaphylla L
نویسنده
چکیده
The present study was aimed at evaluation of the anti-inflammatory, analgesic and antipyretic activities of petroleum ether and ethanolic extract of aerial parts of Mollugo pentaphylla Linn. In experimental standard models. The results showed that the ethanolic extract significantly reduce the edema induced by carrageenan within 1 to 3 hrs. post dosing and Cotton-pellet induced granuloma models than the petroleum ether extract at all the dose levels used. In analgesic activity by tail immersion and acetic acid induced writhing models, ethanolic extract significantly reduce the painful stimulus than petroleum ether extract. This confirms central and peripheral effects of the drugs. It also possess antipyretic activity, ethanolic extract significantly reduces fever at higher doses within 3 hrs. than petroleum ether extract on Brewer ́s yeast induced pyrexia model in rats.
منابع مشابه
Screening of anti-inflammatory activity and dose selection of Mollugo pentaphylla by using cotton pellet induced granuloma in rat
Anti-inflammatory activ ity of the plant Mollugo pentaphylla (Ethanolic Extract) was studied by using sub acute model like cotton pellet induced granuloma technique. Sterilized raw cotton was implanted in the axilla and growing region of the rat. The ethanolic extract of the plant was adminis tered orally (at dose 200mg/kg and 400 mg/kg body weight) by inhibit ing wet weight and dry weight of t...
متن کاملEffects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice
BACKGROUND Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in joints and soft tissues, and it can lead to acute or chronic arthritis. MSU are pro-inflammatory stimuli that can initiate, amplify and sustain an intense inflammatory response. In this study, we evaluated the anti-inflammatory effect of an extract of Mollugo pentaphylla (MPE) on MSU-ind...
متن کاملStudy on Antipyretic Activity of a Mollugo pentaphylla Linn in Albino Mice
The present investigation was carried out to evaluate antipyretic activity of methanolic extract of the whole plant of Mollugo pentaphylla. Subcutaneous injection of sterilized brewer’s yeast suspended in 12 % in saline at the dose of 10 ml / Kg body weight in albino mice leads to pyrexia. The study showed that the extract is safe at doses 0.5 ml / Kg body weight. The results conclude that the ...
متن کاملStudies on Anti-inflammatory, Analgesic and Antipyretic Properties of Methanol Extract of Caesalpinia bonducella leaves in Experimental Animal Models
The methanol extract of Caesalpinia bonducella leaves were investigated for anti-inflammatory, analgesic and antipyretic activity at the doses of 50, 100 and 200 mg/kg, body weight. The experimental paradigms used were carrageenan, dextran, histamine induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, while hot plate and acetic acid induced writhing methods w...
متن کاملOn the Antipyretic, Anti-inflammatory, Analgesic and Molluscicidal Properties of Polyscias Fruticosa (l) Harms
The n-butanol extract of the leaves Polyscias fruticosa (L) Harms (Araliaceae) was tested for its anti-inflammatory activity plethismometrically in egg white induced paw oedema in rats, antipyretic activity and analgesic activity by writhing method phenyl butazone, paracetamol and aspirin were used as positive controls for anti-inflammatory, antipyretic and analgesic activity screening studies...
متن کامل